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Article

Very early-life exposure to microbiota-induced TNF drives the maturation of neonatal pre-cDC1.

Gut - 1 Mar 2021

Köhler Arnaud, Delbauve Sandrine, Smout Justine, Torres David, Flamand Véronique

Abstract excerpt

OBJECTIVE: Induction of immune protection against pathogens is particularly crucial during the neonatal period dominated by anti-inflammatory and tolerance immunity. The preclinical study was carried out to determine whether environmental factors such as microbiota may influence early life immunity by impacting the development and the functional maturation of precursors of type 1 conventional dendritic cells...

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Identifiers

PMID: 32546472
DOI: 10.1136/gutjnl-2019-319700

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