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Article

Transgenic analysis of the Smad family of TGF-beta signal transducers in Drosophila melanogaster suggests new roles and new interactions between family members.

Genetics - 1 Apr 2001

Marquez R M, Singer M A, Takaesu N T, Waldrip W R, Kraytsberg Y, Newfeld S J

Abstract excerpt

Smad signal transducers are required for transforming growth factor-beta-mediated developmental events in many organisms including humans. However, the roles of individual human Smad genes (hSmads) in development are largely unknown. Our hypothesis is that an hSmad performs developmental roles analogous to those of the most similar Drosophila Smad gene (dSmad). We expressed six hSmad and four dSmad transgenes in...

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Identifiers

PMID: 11290719
DOI: 10.1093/genetics/157.4.1639
PMCID: PMC1461598

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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