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Article

The tRNA thiolation pathway modulates the intracellular redox state in Escherichia coli.

Journal of bacteriology - 1 May 2013

Nakayashiki Toru, Saito Natsumi, Takeuchi Rikiya, Kadokura Hiroshi, Nakahigashi Kenji, Wanner Barry L, Mori Hirotada

Abstract excerpt

We have performed a screening of hydroxyurea (HU)-sensitive mutants using a single-gene-deletion mutant collection in Escherichia coli K-12. HU inhibits ribonucleotide reductase (RNR), an enzyme that catalyzes the formation of deoxyribonucleotides. Unexpectedly, seven of the mutants lacked genes that are required for the incorporation of sulfur into a specific tRNA modification base,...

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Identifiers

PMID: 23457245
DOI: 10.1128/JB.02180-12
PMCID: PMC3624572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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