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Article

UBTD1 induces cellular senescence through an UBTD1-Mdm2/p53 positive feedback loop.

The Journal of pathology - 1 Mar 2015

Zhang Xiao-Wei, Wang Xiao-Feng, Ni Su-Jie, Qin Wei, Zhao Li-Qin, Hua Rui-Xi, Lu You-Wei, Li Jin, Dimri Goberdhan P, Guo Wei-Jian

Abstract excerpt

The tumour suppressor p53 plays an important role in tumourigenesis. Besides inducing apoptosis, it regulates cellular senescence, which constitutes an important barrier to tumourigenesis. The mechanism of regulation of cellular senescence by p53 and its downstream pathway are poorly understood. Here, we report that the ubiquitin domain-containing 1 (UBTD1) gene, a new downstream target of p53, induces cellular...

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Source

Identifiers

PMID: 25382750
DOI: 10.1002/path.4478

Genes

UBTD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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