Article
Transcriptional factor Prox1 plays an essential role in the antiproliferative action of interferon-γ in esophageal cancer cells.
Annals of surgical oncology - 1 Dec 2011
Akagami Masatoshi, Kawada Kenji, Kubo Hajime, Kawada Mayumi, Takahashi Meiko, Kaganoi Junichi, Kato Shigeru, Itami Atsushi, Shimada Yutaka, Watanabe Go, Sakai Yoshiharu
Abstract excerpt
BACKGROUND: We previously reported interferon-γ (IFN-γ)-induced apoptosis in 10 (32%) of 31 esophageal squamous cell carcinoma (ESCC) cell lines. However, the molecular basis of antiproliferative action by IFN-γ remains elusive. Here we demonstrate that IFN-γ induces transcriptional factor Prox1, and we explore the link between Prox1 and the IFN-γ system in ESCC cells. METHODS: By using ESCC cell lines, we...
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