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Article

TLR3 deletion limits mortality and disease severity due to Phlebovirus infection.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2006

Gowen Brian B, Hoopes Justin D, Wong Min-Hui, Jung Kie-Hoon, Isakson Kevin C, Alexopoulou Lena, Flavell Richard A, Sidwell Robert W

Abstract excerpt

TLR3 was the first member of the TLR family of pattern recognition receptors found to detect a conserved viral molecular pattern, dsRNA, yet supporting evidence for a major role in host defense against viral pathogens is limited. Punta Toro virus (PTV) has been shown to produce severe infection in mice, modeling disease caused by the related highly pathogenic Rift Valley fever phlebovirus in humans and...

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Source

Identifiers

PMID: 17056560
DOI: 10.4049/jimmunol.177.9.6301

Genes

TLR3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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