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Article

Isolation of JFH-1 strain and development of an HCV infection system.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2009

Wakita Takaji

Abstract excerpt

Detailed analysis of hepatitis C virus (HCV) has been hampered by the lack of an appropriate viral culture system and small animal models of infection. My group and others have recently reported the production of infectious virus after full-length HCV RNA transfection into Huh-7 cells. This system depends primarily on isolation of a JFH-1 strain from a patient with fulminant hepatitis. The JFH-1 strain belongs to...

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PMID: 19009271
DOI: 10.1007/978-1-59745-394-3_23

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