Article
Resident alveolar macrophages are susceptible to and permissive of Coxiella burnetii infection.
PloS one - 1 Jan 2012
Calverley Matthew, Erickson Sara, Read Amanda J, Harmsen Allen G
Abstract excerpt
Coxiella burnetii, the causative agent of Q fever, is a zoonotic disease with potentially life-threatening complications in humans. Inhalation of low doses of Coxiella bacteria can result in infection of the host alveolar macrophage (AM). However, it is not known whether a subset of AMs within the heterogeneous population of macrophages in the infected lung is particularly susceptible to infection. We have found...
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