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A chronic murine model of pulmonary <i>Acinetobacter baumannii</i> infection enabling the investigation of late virulence factors, long-term antibiotic treatments, and polymicrobial infections

2024-09-17

Abstract excerpt

Acinetobacter baumannii can cause prolonged infections that disproportionately affect immunocompromised populations. Our understanding of A. baumannii respiratory pathogenesis relies on an acute murine infection model with limited clinical relevance that employs an unnaturally high number of bacteria and requires the assessment of bacterial load at 24-36 hours post-infection. Here, we demonstrate that low intrana...

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Literature Corpus work
af10e089-f6b2-5a37-9f16-1aa12f8cce96
DOI
10.1101/2024.09.17.613469
Open publication

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A chronic murine model of pulmonary <i>Acinetobacter baumannii</i> infection enabling the investigation of late virulence factors, long-term antibiotic treatments, and polymicrobial infectionsDOI 10.1101/2024.09.17.613469
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