Article

Size Matters: Small Cell Variants of <i>Coxiella burnetii</i> Initiate Replication Early in Primary Macrophages

2026-08-18

Abstract excerpt

Coxiella burnetii alternates morphologies to survive in two niches: the external environment and a degradative intracellular compartment. The small cell variant (SCV) is adapted for environmental persistence and transmission of Q fever to ruminants and humans. The large cell variant (LCV) is intracellular, and despite not being a major source of transmission, is infectious in vitro . When modeling infection, rese...

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Literature Corpus work: abe680f0-4208-5b91-80b4-86d41f9baa78
DOI: 10.64898/2026.08.17.744959

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