Article
Novel modeling of combinatorial miRNA targeting identifies SNP with potential role in bone density.
PLoS computational biology - 1 Jan 2012
Coronnello Claudia, Hartmaier Ryan, Arora Arshi, Huleihel Luai, Pandit Kusum V, Bais Abha S, Butterworth Michael, Kaminski Naftali, Stormo Gary D, Oesterreich Steffi, Benos Panayiotis V
Abstract excerpt
MicroRNAs (miRNAs) are post-transcriptional regulators that bind to their target mRNAs through base complementarity. Predicting miRNA targets is a challenging task and various studies showed that existing algorithms suffer from high number of false predictions and low to moderate overlap in their predictions. Until recently, very few algorithms considered the dynamic nature of the interactions, including the...
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