Article

Allele-specific miRNA-binding analysis identifies candidate target genes for breast cancer risk

2019-09-20

Abstract excerpt

<h4>ABSTRACT</h4> Most breast cancer (BC) risk-associated variants (raSNPs) identified in genome-wide association studies (GWAS) are believed to cis-regulate the expression of genes. We hypothesise that cis-regulatory variants contributing to disease risk may be affecting miRNA genes and/or miRNA-binding. To test this we adapted two miRNA-binding prediction algorithms — TargetScan and miRanda — to perform allele-...

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Literature Corpus work: 8cc801d4-46a3-5989-9046-f7d1a198f7be
DOI: 10.1101/777318

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