Diammonium Glycyrrhizinate Attenuates Aβ_1–42‐Induced Neuroinflammation and Regulates MAPK and NF‐κB Pathways <i>In Vitro</i> and <i>In Vivo</i>

Abstract excerpt

BACKGROUND AND PURPOSE: Beta-amyloid (Aβ)-mediated inflammation contributes to the progression and chronicity of Alzheimer's disease (AD), although the exact mechanism remains unclear. This study aimed to investigate whether diammonium glycyrrhizinate (DG) could inhibit Aβ-induced inflammation in vitro and in vivo and to explore the underlying mechanisms. METHODS: Aβ(1-42) was injected to bilateral hippocampus of...

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