High-mobility group box protein 1 promotes the survival of myeloid-derived suppressor cells by inducing autophagy

Abstract excerpt

Myeloid-derived suppressor cells are immune-suppressive cells that are elevated in most individuals with cancer, where their accumulation and suppressive activity are driven by inflammation. As myeloid-derived suppressor cells inhibit anti-tumor immunity and promote tumor progression, we are determining how their viability is regulated. Previous studies have established that the damage-associated molecular...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Advanced Glycation End Products research
• Share to Autophagy in Disease and Therapy
• Share to Immune cells in cancer