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Article

MYG1 drives glycolysis and colorectal cancer development through nuclear-mitochondrial collaboration

11 Jun 2024

Abstract excerpt

Metabolic remodeling is a strategy for tumor survival under stress. However, the molecular mechanisms during the metabolic remodeling of colorectal cancer (CRC) remain unclear. Melanocyte proliferating gene 1 (MYG1) is a 3'-5' RNA exonuclease and plays a key role in mitochondrial functions. Here, we uncover that MYG1 expression is upregulated in CRC progression and highly expressed MYG1 promotes glycolysis and...

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PMID: 38862489
DOI: 10.1038/s41467-024-49221-0

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