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Article

Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival.

Molecular and cellular biology - 1 Mar 2013

Zurashvili Tinatin, Cordón-Barris Lluís, Ruiz-Babot Gerard, Zhou Xiangyu, Lizcano Jose M, Gómez Nestor, Giménez-Llort Lydia, Bayascas Jose R

Abstract excerpt

3-Phosphoinositide-dependent protein kinase 1 (PDK1) operates in cells in response to phosphoinositide 3-kinase activation and phosphatidylinositol-3,4,5-trisphosphate [PtdIns(3,4,5)P(3)] production by activating a number of AGC kinases, including protein kinase B (PKB)/Akt. Both PDK1 and PKB contain pleckstrin homology (PH) domains that interact with the PtdIns(3,4,5)P(3) second messenger. Disrupting the...

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Source

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Identifiers

PMID: 23275438
DOI: 10.1128/MCB.01052-12
PMCID: PMC3623085

Genes

PDK1
BDNF
FOXO1
TSC2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival.PMID 23275438Read ↗

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