Article
The Causal Effect of Serum Lipid Levels Mediated by Neuregulin 4 on the Risk of Four Atherosclerosis Subtypes: Evidence from Mendelian Randomization Analysis.
Vascular health and risk management - 1 Jan 2024
Zheng Longyi, Zhang Chengjing, Bu Shichang, Guo Wencheng, Li Tongtong, Xu Ying, Liu Yunan, Yuan Caimei, Feng Chengwu, Zong Geng, Zhu Jingwen, Xing Maoying, Geng Xin
Abstract excerpt
Background: Neuregulin 4 (NRG4) was known to be associated with serum lipid levels and atherosclerosis. However, it is unknown whether the role of NRG4 in lipid homeostasis is causal to atherosclerosis and whether the effect is beneficial across different atherosclerosis subtypes. Methods: We investigated the causal role of the levels of serum low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein...
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