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Article

Quantitative contributions of target alteration and decreased drug accumulation to Pseudomonas aeruginosa fluoroquinolone resistance.

Antimicrobial agents and chemotherapy - 1 Mar 2013

Bruchmann Sebastian, Dötsch Andreas, Nouri Bianka, Chaberny Iris F, Häussler Susanne

Abstract excerpt

Quinolone antibiotics constitute a clinically successful and widely used class of broad-spectrum antibiotics; however, the emergence and spread of resistance increasingly limits the use of fluoroquinolones in the treatment and management of microbial disease. In this study, we evaluated the quantitative contributions of quinolone target alteration and efflux pump expression to fluoroquinolone resistance in...

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Identifiers

PMID: 23274661
DOI: 10.1128/AAC.01581-12
PMCID: PMC3591863

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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