Article
Efflux and target mutations as quinolone resistance mechanisms in clinical isolates of Streptococcus pneumoniae.
The Journal of antimicrobial chemotherapy - 1 Apr 2000
Broskey J, Coleman K, Gwynn M N, McCloskey L, Traini C, Voelker L, Warren R
Abstract excerpt
The aim of this study was to characterize quinolone resistance mechanisms in strains of Streptococcus pneumoniae with increased MICs of ofloxacin. These strains were also tested for their susceptibility to a battery of quinolone antimicrobial agents, including gemifloxacin. Of the S. pneumoniae isolates used, 27 were susceptible to ofloxacin, 18 intermediate and 48 resistant (ofloxacin MIC <4, 4 and >4 mg/L,...
Topics
- Anti-Infective Agents
- Bacterial Proteins
- DNA Gyrase
- DNA Topoisomerase IV
- DNA Topoisomerases, Type II
- DNA-Binding Proteins
- Drug Resistance, Microbial
- Fluoroquinolones
- Humans
- Microbial Sensitivity Tests