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Mutations in the gyrA, parC, and mexR genes provide functional insights into the fluoroquinolone-resistant Pseudomonas aeruginosa isolated in Vietnam

1 Feb 2018

Abstract excerpt

Introduction: Pseudomonas aeruginosa has many mechanisms of resistance to fluoroquinolones. The main mechanism is to change the effect of two enzymes that open the DNA helix – the enzyme DNA gyrase ( gyrA ) and the topoisomerase IV ( parC ). In addition, mutations that render the MexAB-oprM pump ( mexR ) dysfunctional, leading to its overexpression, also enhance resistance to fluoroquinolones. In this study, we...

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PMID: 29535543
DOI: 10.2147/idr.s147581

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