Article
Evaluation of fluoroquinolone resistance mechanisms in Pseudomonas aeruginosa multidrug resistance clinical isolates.
Microbial drug resistance (Larchmont, N.Y.) - 1 Feb 2012
Pasca Maria Rosalia, Dalla Valle Claudia, De Jesus Lopes Ribeiro Ana Luisa, Buroni Silvia, Papaleo Maria Cristiana, Bazzini Silvia, Udine Claudia, Incandela Maria Loreto, Daffara Silvio, Fani Renato, Riccardi Giovanna, Marone Piero
Abstract excerpt
Efflux transporters have a considerable role in the multidrug resistance (MDR) of Pseudomonas aeruginosa, an important nosocomial pathogen. In this study, 45 P. aeruginosa clinical strains, with an MDR phenotype, have been isolated in a hospital of Northern Italy and characterized to identify the mechanisms responsible for their fluoroquinolone (FQ) resistance. These isolates were analyzed for clonal similarity,...
Topics
- Anti-Bacterial Agents
- Bacterial Proteins
- DNA Gyrase
- Drug Resistance, Multiple, Bacterial
- Fluoroquinolones
- Gene Expression Regulation, Bacterial
- Genes, Regulator
- Humans
- Membrane Transport Proteins