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Article

Use of a genetic approach to evaluate the consequences of inhibition of efflux pumps in Pseudomonas aeruginosa.

Antimicrobial agents and chemotherapy - 1 Jun 1999

Lomovskaya O, Lee A, Hoshino K, Ishida H, Mistry A, Warren M S, Boyer E, Chamberland S, Lee V J

Abstract excerpt

Drug efflux pumps in Pseudomonas aeruginosa were evaluated as potential targets for antibacterial therapy. The potential effects of pump inhibition on susceptibility to fluoroquinolone antibiotics were studied with isogenic strains that overexpress or lack individual efflux pumps and that have various combinations of efflux- and target-mediated mutations. Deletions in three efflux pump operons were constructed....

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Identifiers

PMID: 10348749
DOI: 10.1128/AAC.43.6.1340
PMCID: PMC89275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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