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Whole genome HBV deletion profiles and the accumulation of preS deletion mutant during antiviral treatment

1 Dec 2012

Abstract excerpt

BACKGROUND: Hepatitis B virus (HBV), because of its error-prone viral polymerase, has a high mutation rate leading to widespread substitutions, deletions, and insertions in the HBV genome. Deletions may significantly change viral biological features complicating the progression of liver diseases. However, the clinical conditions correlating to the accumulation of deleted mutants remain unclear. In this study, we...

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PMID: 23272650
DOI: 10.1186/1471-2180-12-307

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