Article
Hepatocellular carcinoma-associated single-nucleotide variants and deletions identified by the use of genome-wide high-throughput analysis of hepatitis B virus.
The Journal of pathology - 1 Oct 2017
Liu Wen-Chun, Wu I-Chin, Lee Yen-Chien, Lin Chih-Peng, Cheng Ji-Hong, Lin Yih-Jyh, Yen Chia-Jui, Cheng Pin-Nan, Li Pei-Fu, Cheng Yi-Ting, Cheng Pei-Wen, Sun Koun-Tem, Yan Shu-Ling, Lin Jia-Jhen, Yang Jui-Chu, Chang Kung-Chao, Ho Cheng-Hsun, Tseng Vincent S, Chang Bill Chia-Han, Wu Jaw-Ching, Chang Ting-Tsung
Abstract excerpt
This study investigated hepatitis B virus (HBV) single-nucleotide variants (SNVs) and deletion mutations linked with hepatocellular carcinoma (HCC). Ninety-three HCC patients and 108 non-HCC patients were enrolled for HBV genome-wide next-generation sequencing (NGS) analysis. A systematic literature review and a meta-analysis were performed to validate NGS-defined HCC-associated SNVs and deletions. The...
Topics
- Carcinoma, Hepatocellular
- DNA Repair
- Endoplasmic Reticulum Stress
- Gene Deletion
- Genome, Viral
- Hepatitis B virus
- Hepatitis B, Chronic
- Humans
- Liver Neoplasms