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Article

Molecular mechanism by which a potent hepatitis C virus NS3-NS4A protease inhibitor overcomes emergence of resistance.

The Journal of biological chemistry - 22 Feb 2013

O'Meara Jeff A, Lemke Christopher T, Godbout Cédrickx, Kukolj George, Lagacé Lisette, Moreau Benoît, Thibeault Diane, White Peter W, Llinàs-Brunet Montse

Abstract excerpt

Although optimizing the resistance profile of an inhibitor can be challenging, it is potentially important for improving the long term effectiveness of antiviral therapy. This work describes our rational approach toward the identification of a macrocyclic acylsulfonamide that is a potent inhibitor of the NS3-NS4A proteases of all hepatitis C virus genotypes and of a panel of genotype 1-resistant variants. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23271737
DOI: 10.1074/jbc.M112.439455
PMCID: PMC3581377

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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