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Article

In vitro resistance profile of the hepatitis C virus NS3 protease inhibitor BI 201335.

Antimicrobial agents and chemotherapy - 1 Jan 2012

Lagacé Lisette, White Peter W, Bousquet Christiane, Dansereau Nathalie, Dô Florence, Llinas-Brunet Montse, Marquis Martin, Massariol Marie-Josée, Maurice Roger, Spickler Catherine, Thibeault Diane, Triki Ibtissem, Zhao Songping, Kukolj George

Abstract excerpt

The in vitro resistance profile of BI 201335 was evaluated through selection and characterization of variants in genotype 1a (GT 1a) and genotype 1b (GT 1b) replicons. NS3 R155K and D168V were the most frequently observed resistant variants. Phenotypic characterization of the mutants revealed shifts in sensitivity specific to BI 201335 that did not alter susceptibility to alpha interferon. In contrast to...

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Identifiers

PMID: 22024816
DOI: 10.1128/AAC.05166-11
PMCID: PMC3256085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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