Article
Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel.
Hepatology (Baltimore, Md.) - 1 Jul 2011
Foster Toshana L, Verow Mark, Wozniak Ann L, Bentham Matthew J, Thompson Joseph, Atkins Elizabeth, Weinman Steven A, Fishwick Colin, Foster Richard, Harris Mark, Griffin Stephen
Abstract excerpt
UNLABELLED: The hepatitis C virus (HCV) p7 ion channel plays a critical role during infectious virus production and represents an important new therapeutic target. Its activity is blocked by structurally distinct classes of small molecules, with sensitivity varying between isolate p7 sequences. Although this is indicative of specific protein-drug interactions, a lack of high-resolution structural information has...
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