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Article

A risk marker of tribasic hemagglutinin cleavage site in influenza A (H9N2) virus.

Communications biology - 15 Jan 2021

Zhang Jiahao, Ma Kaixiong, Li Bo, Chen Yiqun, Qiu Ziwen, Xing Jinchao, Huang Jinyu, Hu Chen, Huang Yifan, Li Huanan, Liu Dingxiang, Liao Ming, Qi Wenbao

Abstract excerpt

Low pathogenic avian influenza A(H9N2) virus is endemic worldwide and continually recruit internal genes to generate human-infecting H5N1, H5N6, H7N9, and H10N8 influenza variants. Here we show that hemagglutinin cleavage sites (HACS) of H9N2 viruses tended to mutate towards hydrophilic via evolutionary transition, and the tribasic HACS were found at high prevalence in Asia and the Middle East. Our finding...

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Identifiers

PMID: 33452423
DOI: 10.1038/s42003-020-01589-7
PMCID: PMC7811019

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