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Article

Non-basic amino acids in the hemagglutinin proteolytic cleavage site of a European H9N2 avian influenza virus modulate virulence in turkeys.

Scientific reports - 4 Dec 2020

Blaurock Claudia, Scheibner David, Landmann Maria, Vallbracht Melina, Ulrich Reiner, Böttcher-Friebertshäuser Eva, Mettenleiter Thomas C, Abdelwhab Elsayed M

Abstract excerpt

H9N2 avian influenza virus (AIV) is the most widespread low pathogenic (LP) AIV in poultry and poses a serious zoonotic risk. Vaccination is used extensively to mitigate the economic impact of the virus. However, mutations were acquired after long-term circulation of H9N2 virus in poultry, particularly in the hemagglutinin (HA) proteolytic cleavage site (CS), a main virulence determinant of AIV. Compared to...

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PMID: 33277593
DOI: 10.1038/s41598-020-78210-8
PMCID: PMC7718272

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Source receipt: pubmed, retrieved 7 Sept 2026.

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