Article
Non-basic amino acids in the hemagglutinin proteolytic cleavage site of a European H9N2 avian influenza virus modulate virulence in turkeys.
Scientific reports - 4 Dec 2020
Blaurock Claudia, Scheibner David, Landmann Maria, Vallbracht Melina, Ulrich Reiner, Böttcher-Friebertshäuser Eva, Mettenleiter Thomas C, Abdelwhab Elsayed M
Abstract excerpt
H9N2 avian influenza virus (AIV) is the most widespread low pathogenic (LP) AIV in poultry and poses a serious zoonotic risk. Vaccination is used extensively to mitigate the economic impact of the virus. However, mutations were acquired after long-term circulation of H9N2 virus in poultry, particularly in the hemagglutinin (HA) proteolytic cleavage site (CS), a main virulence determinant of AIV. Compared to...
Topics
- Amino Acid Motifs
- Amino Acids
- Animals
- Brain
- Cats
- Databases, Genetic
- HEK293 Cells
- Hemagglutinin Glycoproteins, Influenza Virus
- Hemagglutinins
- Humans
- Influenza A Virus, H9N2 Subtype
- Influenza in Birds
- Mutation