Article
ATARiS: computational quantification of gene suppression phenotypes from multisample RNAi screens.
Genome research - 1 Apr 2013
Shao Diane D, Tsherniak Aviad, Gopal Shuba, Weir Barbara A, Tamayo Pablo, Stransky Nicolas, Schumacher Steven E, Zack Travis I, Beroukhim Rameen, Garraway Levi A, Margolin Adam A, Root David E, Hahn William C, Mesirov Jill P
Abstract excerpt
Genome-scale RNAi libraries enable the systematic interrogation of gene function. However, the interpretation of RNAi screens is complicated by the observation that RNAi reagents designed to suppress the mRNA transcripts of the same gene often produce a spectrum of phenotypic outcomes due to differential on-target gene suppression or perturbation of off-target transcripts. Here we present a computational method,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.