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Article

How can functional annotations be derived from profiles of phenotypic annotations?

BMC bioinformatics - 10 Feb 2017

Serrano-Solano Beatriz, Díaz Ramos Antonio, Hériché Jean-Karim, Ranea Juan A G

Abstract excerpt

BACKGROUND: Loss-of-function phenotypes are widely used to infer gene function using the principle that similar phenotypes are indicative of similar functions. However, converting phenotypic to functional annotations requires careful interpretation of phenotypic descriptions and assessment of phenotypic similarity. Understanding how functions and phenotypes are linked will be crucial for the development of...

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PMID: 28183267
DOI: 10.1186/s12859-017-1503-5
PMCID: PMC5304448

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