Article
The LRRK2 gene is mutated in a Chinese autosomal-dominant Parkinson's disease family.
Genetic testing and molecular biomarkers - 1 Feb 2013
Guo Rui, Hu Xinyu, Chen Qiuhui, Zhang Ying, Zhang Yizhi, Sun Yajuan, Hu Guohua
Abstract excerpt
The mutation of the leucine-rich repeat kinase2 gene (LRRK2) is the most commonly detected genetic determinant of Parkinson's disease (PD). However, the specific role of the LRRK2 mutation in the occurrence of the autosomal-dominant family PD remains to be elucidated. In this study, we report a large Chinese LRRK2-related PD family with 33 members of four generations. Genomic DNA was isolated from peripheral...
Topics
- Adult
- Asian People
- Female
- Genetic Predisposition to Disease
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male
- Middle Aged
- Mutation
- Parkinson Disease
- Pedigree