Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Establishment and characterization of a novel xenograft model of human gastrointestinal stromal tumor in mice.

Anticancer research - 1 Jan 2013

Moriyama Makoto, Shimada Yutaka, Nagata Takuya, Omura Tetsuya, Sekine Shinichi, Matsui Koshi, Yoshioka Isaku, Okumura Tomoyuki, Sawada Shigeaki, Yoshida Toru, Tsukada Kazuhiro

Abstract excerpt

BACKGROUND: The clinical outcome of gastrointestinal stromal tumor (GIST) has been improved by the introduction of molecular-targeting drugs. However, resistance to these drugs appears during the course of treatment. The aim of this study was to establish and characterize a human xenograft model of GIST. MATERIALS AND METHODS: GIST tissue from a patient with esophageal GIST was implanted under the skin of a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzamides
Share to Esophageal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastrointestinal Stromal Tumors

Share to Imatinib Mesylate

Share to Piperazines

Share to Pyrroles

Share to Sunitinib

Share to Transplantation, Heterologous

Source

Identifiers

PMID: 23267143

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Establishment and characterization of a novel xenograft model of human gastrointestinal stromal tumor in mice.PMID 23267143Read ↗

Establishment and characterization of a human gastrointestinal stromal tumour (GIST) xenograft in athymic nude mice.Semantic proximity Read ↗

Patient-derived xenograft models of gastrointestinal stromal tumors provide a ready-to-use platform for translational research.Semantic proximity Read ↗

[Establishment and pathologic analysis of imatinib-resistant gastrointestinal stromal tumor xenografts].Semantic proximity Read ↗

Sorafenib induces growth suppression in mouse models of gastrointestinal stromal tumor.Semantic proximity Read ↗

Treatment of gastrointestinal stromal tumor after imatinib and sunitinib.Semantic proximity Read ↗

Regorafenib regresses an imatinib-resistant recurrent gastrointestinal stromal tumor (GIST) with a mutation in exons 11 and 17 of c-kit in a patient-derived orthotopic xenograft (PDOX) nude mouse model.Semantic proximity Read ↗

C-kit-targeted imaging of gastrointestinal stromal tumor using radiolabeled anti-c-kit monoclonal antibody in a mouse tumor model.Semantic proximity Read ↗

The V654A second-site KIT mutation increases tumor oncogenesis and STAT activation in a mouse model of gastrointestinal stromal tumor.Semantic proximity Read ↗

In vivo effect of imatinib on progression of cecal GIST-like tumors in exon 17-type c-kit knock-in mice.Semantic proximity Read ↗

[Immunotherapy of Gastrointestinal Stromal Tumors].Semantic proximity Read ↗

Knowns and Known Unknowns of Gastrointestinal Stromal Tumor Adjuvant Therapy.Semantic proximity Read ↗

Antitumor Efficacy of the Novel KIT Inhibitor IDRX-42 (Formerly M4205) in Patient- and Cell Line-Derived Xenograft Models of Gastrointestinal Stromal Tumor (GIST).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.