Article
Regorafenib regresses an imatinib-resistant recurrent gastrointestinal stromal tumor (GIST) with a mutation in exons 11 and 17 of c-kit in a patient-derived orthotopic xenograft (PDOX) nude mouse model.
Cell cycle (Georgetown, Tex.) - 1 Jan 2018
Miyake Kentaro, Kawaguchi Kei, Kiyuna Tasuku, Miyake Masuyo, Igarashi Kentaro, Zhang Zhiying, Murakami Takashi, Li Yunfeng, Nelson Scott D, Elliott Irmina, Russell Tara, Singh Arun, Hiroshima Yukihiko, Momiyama Masashi, Matsuyama Ryusei, Chishima Takashi, Endo Itaru, Eilber Fritz C, Hoffman Robert M
Abstract excerpt
Gastrointestinal stromal tumor (GIST) with a mutation in exons 11 and 17 of c-kit is a rare type of sarcoma. The aim of this study was to determine drug sensitivity for a regionally-recurrent case of GIST using a patient-derived orthotopic xenograft (PDOX) model. The PDOX model was established in the anterior wall of the stomach. GIST PDOX models were randomized into 5 groups of 6 mice each when the tumor volume...
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