Article
In vivo effect of imatinib on progression of cecal GIST-like tumors in exon 17-type c-kit knock-in mice.
Laboratory investigation; a journal of technical methods and pathology - 1 Oct 2009
Ishikawa Takashi, Nakai Norihiro, Liu Ning-Ning, Shiba Kazuhiro, Isozaki Koji, Matsuda Ikuo, Ito Takashi, Fujimoto Jiro, Hatakeyama Katsuyoshi, Kanda Tatsuo, Hirota Seiichi
Abstract excerpt
Two families with a germline Asp820Tyr mutation at exon 17 of the c-kit gene and multiple gastrointestinal stromal tumors (GISTs) have been reported. Recently, we generated a knock-in mouse model of the family, and mice with KIT-Asp818Tyr corresponding to human KIT-Asp820Tyr showed a cecal GIST-like tumor. In this report, we examined the in vivo effect of imatinib on tumor progression in knock-in mice. Imatinib...
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