Article
Treatment of gastrointestinal stromal tumor after imatinib and sunitinib.
Current opinion in oncology - 1 Jul 2011
Montemurro Michael, Bauer Sebastian
Abstract excerpt
PURPOSE OF REVIEW: Tyrosine kinase inhibitors (TKIs), such as imatinib and sunitinib, have changed the outcome of patients with gastrointestinal stromal tumor (GIST) and prolonged survival by many-fold. Unfortunately, treatment failure and tumor progression seem inevitable over time and constitute an unresolved clinical challenge. This article reviews current efforts to overcome drug resistance and progression....
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