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Article

Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion.

Nature cell biology - 1 Feb 2013

Xue Bin, Krishnamurthy Kannan, Allred D Craig, Muthuswamy Senthil K

Abstract excerpt

The mechanisms by which tumour cells metastasize and the role that cell polarity proteins play in this process are not well understood. We report that partitioning defective protein 3 (Par3) is dysregulated in metastasis in human breast cancer, and is associated with a higher tumour grade and ErbB2-positive status. Downregulation of Par3 cooperated with ErbB2 to induce cell invasion and metastasis in vivo....

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Identifiers

PMID: 23263278
DOI: 10.1038/ncb2663
PMCID: PMC4577246

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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