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Article

Paradigms lost-an emerging role for over-expression of tight junction adhesion proteins in cancer pathogenesis.

1 Aug 2015

Abstract excerpt

Tight junctions (TJ) are multi-protein complexes located at the apicalmost tip of the lateral membrane in polarised epithelial and endothelial cells. Their principal function is in mediating intercellular adhesion and polarity. Accordingly, it has long been a paradigm that loss of TJ proteins and consequent deficits in cell-cell adhesion are required for tumour cell dissemination in the early stages of the...

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PMID: 26366401
DOI: 10.3978/j.issn.2305-5839.2015.08.01

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