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Article

Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells.

Breast cancer research : BCR - 1 Jan 2005

Baugher Paige J, Krishnamoorthy Lakshmi, Price Janet E, Dharmawardhane Surangani F

Abstract excerpt

INTRODUCTION: The metastatic progression of cancer is a direct result of the disregulation of numerous cellular signaling pathways, including those associated with adhesion, migration, and invasion. Members of the Rac family of small GTPases are known to act as regulators of actin cytoskeletal structures and strongly influence the cellular processes of integrin-mediated adhesion and migration. Even though...

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Identifiers

PMID: 16280046
DOI: 10.1186/bcr1329
PMCID: PMC1410764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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