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Article

Loss of polarity protein Par3, via transcription factor Snail, promotes bladder cancer metastasis.

Cancer science - 1 Jul 2021

Wang Shenyi, Cai Jinming, Zhang Si, Dong Mingwei, Zhang Li, Xu Yingying, Shen Bing, Chen She

Abstract excerpt

Bladder cancer (BLCA) remains the leading cause of cancer-related mortality among genitourinary malignancies worldwide. BLCA metastasis represents the primary reason for its poor prognosis. In this study, we report that decreased expression of partitioning defective 3 (Par3), a polarity protein (encoded by PARD3), is associated with tumor aggressive phenotypes and poor prognosis in BLCA patients. Consistently,...

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Source

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Identifiers

PMID: 33931921
DOI: 10.1111/cas.14920
PMCID: PMC8253273

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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