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Article

Mathematical models of gene amplification with applications to cellular drug resistance and tumorigenicity.

Genetics - 1 Jul 1990

Kimmel M, Axelrod D E

Abstract excerpt

An increased number of copies of specific genes may offer an advantage to cells when they grow in restrictive conditions such as in the presence of toxic drugs, or in a tumor. Three mathematical models of gene amplification and deamplification are proposed to describe the kinetics of unstable phenotypes of cells with amplified genes. The models differ in details but all assume probabilistic mechanisms of increase...

Topics

Animals
Carcinogenicity Tests
Cell Division
Cell Line
Drug Resistance
Gene Amplification
Genes
Kinetics
Mathematics
Methotrexate
Mice
Models, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oncogenes

Phenotype

Probability

Tetrahydrofolate Dehydrogenase

Source

Open in PubMed Open full text

Identifiers

PMID: 2379824
DOI: 10.1093/genetics/125.3.633
PMCID: PMC1204089

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2379824-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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