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Article

Novel submicroscopic extrachromosomal elements containing amplified genes in human cells.

Nature - 1 Jan 2000

Maurer B J, Lai E, Hamkalo B A, Hood L, Attardi G

Abstract excerpt

In previous work, several methotrexate (MTX)-resistant variants were isolated frm the human cell line HeLa BU25, which exhibited a high degree of dihydrofolate (DHFR) gene amplification (estimated to be 250- to 300-fold). These variants did not contain any chromosome with a homogeneously staining region (HSR) and exhibited only a small average number of minute chromosomes per cell: these two types of karyotypic...

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Source

Identifiers

PMID: 3587364
DOI: 10.1038/327434a0

Genes

DHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Novel submicroscopic extrachromosomal elements containing amplified genes in human cells.PMID 3587364Read ↗

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