Article
Relationship between genetic variant in pre-microRNA-146a and genetic predisposition to temporal lobe epilepsy: a case-control study.
Gene - 1 Mar 2013
Manna Ida, Labate Angelo, Mumoli Laura, Pantusa Maria, Ferlazzo Edoardo, Aguglia Umberto, Quattrone Aldo, Gambardella Antonio
Abstract excerpt
There is evidence that inflammatory mechanisms play a role in the pathogenesis of temporal lobe epilepsy (TLE). MicroRNAs (miRNAs), a class of small non-coding endogenous RNAs, which negatively regulate target gene expression, have shown different expression patterns in immune diseases. Recently, several miRNAs have been found to be differentially expressed in animal models of TLE. To understand the role of...
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