Article
No association of pre-microRNA-146a rs2910164 polymorphism and risk of hepatocellular carcinoma development in Turkish population: a case-control study.
Gene - 15 Oct 2011
Akkız Hikmet, Bayram Süleyman, Bekar Aynur, Akgöllü Ersin, Usküdar Oğuz, Sandıkçı Macit
Abstract excerpt
AIM: MicroRNAs (miRNAs) are an abundant class of small non-protein coding RNAs with posttranscriptional regulatory functions as tumor suppressors and oncogenes. Aberrant expression and structural alteration of miRNAs are considered to participate in tumorigenesis and cancer development. It has been suggested that the presence of single nucleotide polymorphisms in precursor miRNAs (pre-miRNAs) can alter miRNA...
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