Article
A functional polymorphism in the promoter region of microRNA-146a is associated with the risk of Alzheimer disease and the rate of cognitive decline in patients.
PloS one - 1 Jan 2014
Cui Lili, Li You, Ma Guoda, Wang Yan, Cai Yujie, Liu Shengyuan, Chen Yanyan, Li Jia, Xie Yuliu, Liu Gen, Zhao Bin, Li Keshen
Abstract excerpt
miR146a is well known for its regulatory role in the immune response and inflammation. Recent studies have demonstrated the links between miR146a and Alzheimer disease (AD) and suggested that miR146a may be involved in neuroinflammation and the metabolism of amyloid-β (Aβ), which are critical events in AD pathology. Although genetic studies have focused on the association between the miR146a gene and...
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