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The single nucleotide variant n.60G>C in the microRNA-146a associated with susceptibility to drug-resistant epilepsy.

Epilepsy research - 1 May 2020

Boschiero Matheus Negri, Camporeze Bruno, Santos Jéssica Silva Dos, Costa Leandro Borsari da, Bonafé Gabriel Alves, Queiroz Luciano de Souza, Van Roost Dirk, Marson Fernando Augusto Lima, de Aguiar Paulo Henrique Pires, Ortega Manoela Marques

Abstract excerpt

OBJECTIVE: The aim of this study was to evaluate single nucleotide variants (SNVs) n.-411A > G (rs57095329) and n.60 G > C (rs2910164) in microRNA (miR)-146a, related to suppressing of TRAF6 with risk for epilepsy, as well as miR-146a and TRAF6 levels. METHODS: DNAs were extracted from epileptogenic tissues and blood leukocytes from drug-resistant epilepsy patients and healthy-individuals, respectively. Genotypes...

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PMID: 32155539
DOI: 10.1016/j.eplepsyres.2020.106305

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