Genetic association of miRNA-146a with systemic lupus erythematosus in Europeans through decreased expression of the gene.

doi:10.1038/gene.2011.84

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Article

Genetic association of miRNA-146a with systemic lupus erythematosus in Europeans through decreased expression of the gene.

Genes and immunity - 1 Apr 2012

Löfgren S E, Frostegård J, Truedsson L, Pons-Estel B A, D'Alfonso S, Witte T, Lauwerys B R, Endreffy E, Kovács L, Vasconcelos C, Martins da Silva B, Kozyrev S V, Alarcón-Riquelme M E

Abstract excerpt

A recent genome-wide association study revealed a variant (rs2431697) in an intergenic region, between the pituitary tumor-transforming 1 (PTTG1) and microRNA (miR-146a) genes, associated with systemic lupus erythematosus (SLE) susceptibility. Here, we analyzed with a case-control design this variant and other candidate polymorphisms in this region together with expression analysis in order to clarify to which...

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PMID: 22218224
DOI: 10.1038/gene.2011.84
PMCID: PMC3640319

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PTTG1

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