Article
Single-Base Gene Variants in MIR-146A and SCN1A Genes Related to the Epileptogenic Process in Drug-Responsive and Drug-Resistant Temporal Lobe Epilepsy-A Preliminary Study in a Brazilian Cohort Sample.
International journal of molecular sciences - 30 May 2024
Buainain Renata Parissi, Sodré André Rodrigues, Dos Santos Jéssica Silva, Takazaki Karen Antonia Girotto, Queiroz Luciano de Souza, de Oliveira Carlos Tadeu Parisi, de Aguiar Paulo Henrique Pires, Marson Fernando Augusto Lima, Ortega Manoela Marques
Abstract excerpt
The drug-resistant temporal lobe epilepsy (TLE) has recently been associated with single nucleotide variants (SNVs) in microRNA(miR)-146a (MIR-146A) (rs2910164) and Sodium Voltage-Gated Channel Alpha Subunit 1 (SCN1A) (rs2298771 and rs3812718) genes. Moreover, no studies have shown an association between these SNVs and susceptibility to drug-resistant and drug-responsive TLE in Brazil. Thus, deoxyribonucleic acid...
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