Article
A functional polymorphism of the microRNA-146a gene is associated with susceptibility to drug-resistant epilepsy and seizures frequency.
Seizure - 1 Apr 2015
Cui Lili, Tao Hua, Wang Yan, Liu Zhou, Xu Zhien, Zhou Haihong, Cai Yujie, Yao Lifen, Chen Beichu, Liang Wandong, Liu Yu, Cheng Wanwen, Liu Tingting, Ma Guoda, Li You, Zhao Bin, Li Keshen
Abstract excerpt
PURPOSE: Epilepsy is the third most common chronic brain disorder and is characterized by an enduring predisposition for seizures. Recently, a growing body of evidence has suggested that microRNA-146a (miR-146a) is upregulated in the brains of epilepsy patients and of mouse models; furthermore, miR-146a may be involved in the development and progression of seizures through the regulation of inflammation and...
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