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Article

Catalytic efficiency of dehaloperoxidase A is controlled by electrostatics--application of the vibrational Stark effect to understand enzyme kinetics.

Biochemical and biophysical research communications - 18 Jan 2013

Schkolnik Gal, Utesch Tillmann, Zhao Junjie, Jiang Shu, Thompson Matthew K, Mroginski Maria-Andrea, Hildebrandt Peter, Franzen Stefan

Abstract excerpt

The vibrational Stark effect is gaining popularity as a method for probing electric fields in proteins. In this work, we employ it to explain the effect of single charge mutations in dehaloperoxidase-hemoglobin A (DHP A) on the kinetics of the enzyme. In a previous communication published in this journal (BBRC 2012, 420, 733-737) it has been shown that an increase in the overall negative charge of DHP A through...

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Identifiers

PMID: 23261457
DOI: 10.1016/j.bbrc.2012.12.047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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